产品介绍
Product Description
Biochem/physiol Actions
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor.
Features and Benefits
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | , dark red to purple |
| solubility | H2O: 2 mg/mL (clear solution, warmed) |
| storage temp. | 2-8°C |
| SMILES string | CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34 |
| InChI | 1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+ |
| InChI key | MENDIXKFTXYTHJ-HPBPSMLHSA-N |
