General description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormoneactivated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins,translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This genecontains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in theN-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscularatrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Twoalternatively spliced variants encoding distinct isoforms have been described.
Immunogen
Peptide sequence around phosphorylation site of serine 213 (E-A-S(p)-G-A), according to the protein AR.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~110 kDa |
| species reactivity | human |
| concentration | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200,western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (E-A-SP-G-A) |
| NCBI accession no. | NP_000035.2 |
| UniProt accession no. | P10275 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer213) |
| Gene Information | human ... AR(367) |
