产品介绍
Product Description
Application
SMER28 may be used in mTOR-mediated signaling studies.
Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy.
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.
技术参数
Specifications
| Quality Segment | 100 |
| assay | >99% (HPLC) |
| form | solid |
| solubility | DMSO: >20 mg/mL,H2O: insoluble |
| storage temp. | 2-8°C |
| SMILES string | Brc1ccc2ncnc(NCC=C)c2c1 |
| InChI | 1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15) |
| InChI key | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
