产品介绍
Product Description
Application
Wee1, active from rat may be used to study apoptotic signaling.
Biochem/physiol Actions
Protein inhibitor of Cdk2 kinase
Wee1 is a protein tyrosine kinase that phosphorylates Cdc2 on Tyr15 and hence inactivates the CDK1 and CDK2, which facilitates in the negative regulation of entry of cells into mitosis. Increased level of wee1 stimulates Human Immunodeficiency Virus type 1 (HIV-1) Vpr induced cell cycle arrest at G2/M transition followed by apoptosis.
Physical form
Solution in 50 mM Tris-HCl, pH 7.5, 1 mM EDTA, 1 mM DTT, 10% Glycerol
Other Notes
One unit of Wee 1 is defined as the amount of Wee 1 which inhibits 90% of the activity of 10 units of Cdk2
技术参数
Specifications
| biological source | rat |
| Quality Segment | 200 |
| recombinant | expressed in E. coli |
| form | solution |
| mol wt | ~110 kDa |
| UniProt accession no. | Q63802 |
| application(s) | cell analysis |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | rat ... Wee1(308937) |
