产品介绍
Product Description
Application
NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
Biochem/physiol Actions
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: >20 mg/mL at 60 °C,H2O: insoluble |
| storage temp. | 2-8°C |
| SMILES string | CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl |
| InChI | 1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) |
| InChI key | KNADXBVKFAUMCR-UHFFFAOYSA-N |
| Gene Information | human ... CRHR1(1394) |
