Biochem/physiol Actions
MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acting as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor. Both Myc and Mad, as well as the more recently described Mnt and Mga proteins, form heterodimers with Max, permitting binding to specific DNA sequences. These DNA-bound heterodimers recruit coactivator or corepressor complexes that generate alterations in chromatin structure, which in turn modulate transcription. The wild-type c-Myc and c-Myc/MadBR proteins have indistinguishable biological activity and target gene recognition in vivo.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
| biological source | human |
| recombinant | expressed in E. coli |
| assay | ≥80% (SDS-PAGE) |
| form | frozen liquid |
| mol wt | ~26.6 kDa |
| packaging | pkg of 10 μg |
| concentration | 1200 μg/mL |
| color | clear colorless |
| NCBI accession no. | NM_002357 |
| UniProt accession no. | Q05195 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... MXD1(4084) |
