General description
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
Immunogen
Peptide sequence around aa. 637-641 (P-K-S-V-S), according to the protein IRS1.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~180 kDa |
| species reactivity | mouse, human, rat |
| concentration | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200,western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (P-K-S-V-S) |
| NCBI accession no. | NP_005535.1 |
| UniProt accession no. | P35568 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... IRS1(3667) |
