产品介绍
Product Description
Biochem/physiol Actions
Solithromycin is an orally available, broad spectrum, and potent anti-microbial and anti-inflammatory macrolide/fluoroketolide that is effective against respiratory tract pathogens associated with CABP, including macrolide-resistant strains, compared with other available macrolides. Solithromycin significantly inhibits production of TNFα, CXCL8 and MMP9. Also Solithromycin inhibits NF-κB activity under conditions of oxidative stress. Solithromycin exhibits superior anti-microbial and anti-inflammatory activities and is a potential therapy for refractory COPD.
orally available, broad spectrum, and potent anti-microbial and anti-inflammatory macrolide/fluoroketolide
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | O=C([C@@H](C[C@](C)([C@@H]([C@H](C1=O)C)O[C@]2([C@@H]([C@H](C[C@H](O2)C)N(C)C)O)[H])OC)C)[C@@H]([C@@H]3[C@](C)([C@H](OC([C@@]1(C)F)=O)CC)OC(N3CCCCN4C=C(N=N4)C5=CC(N)=CC=C5)=O)C |
| InChI | 1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26-,27+,31+,32-,34-,35-,37-,38+,41-,42-,43-/m1/s1 |
| InChI key | IXXFZUPTQVDPPK-QIFQIIIXSA-N |
