General description
Glucocorticoid receptor (GR) gene/NR3C1 (nuclear receptor subfamily 3 group C member 1) is located on human chromosome 5q31. It belongs to the steroid receptor superfamily that has ligand-activated nuclear transcription factors.
Immunogen
The antiserum was produced against synthesized peptide derived from human GR around the phosphorylation site of Ser226.
Immunogen Range: 201-250
Biochem/physiol Actions
The glucocorticoid receptor (GR) gene/(NR3C1) is associated with asthma. It is required for glucose homeostasis and has been associated with hyperinsulinemia and increased fat deposition. GR also regulates cell differentiation, nervous and immune system functions.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 85 kDa |
| species reactivity | mouse, rat, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:5000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000 |
| NCBI accession no. | P04150 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer226) |
| Gene Information | human ... GCR(2908) |
