General description
Fibroblast growth factor receptor 4 (FGFR4) protein is a tyrosine kinase (TK) receptor comprising an extracellular domain, a transmembrane domain, and an intracellular domain. FGFR4 is expressed in the adrenal cortex, bile duct, cervix, cornea, heart, hepatocyte, intestine, kidney, liver, lung, lymph node, mammary gland, muscle, ovary, pituitary gland, renal tubular epithelium, retina, skin, spleen, stomach, ureter, urothelium, and uterus. FGFR4 gene is located on human chromosome 5q35.2.
Immunogen
Peptide sequence around phosphorylation site of tyrosine 642(I-D-Y(p)-Y-K) derived from Human FGFR4 .
Biochem/physiol Actions
Fibroblast growth factor receptor 4 (FGFR4) protein possesses tyrosine-protein kinase activity and serves as a cell-surface receptor for fibroblast growth factors. It regulates cell proliferation, differentiation, and migration. FGFR4 also participates in survival during embryonic development. It helps with tissue homeostasis, tissue repair, angiogenesis, and inflammation in adults. FGFR4 is expressed at a high level in various cancer types. It plays a key role in tumor subtype differentiation in luminal breast cancer and metastatic disease. Oncogenic mutations of the FGFR4 gene are associated with rhabdomyosarcoma (RMS) and primary gastric cancer.
The antibody detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 90 kDa |
| species reactivity | human |
| concentration | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| isotype | IgG |
| accession no. | NP_002002.3. |
| UniProt accession no. | P22455 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr642) |
| Gene Information | human ... FGFR4(2264) |
