General description
Anti-FZD3 Antibody detects endogenous levels of total FZD3 protein.
The FZD3 (frizzled class receptor 3) gene is mapped to human chromosome 8p21.1. It codes for a receptor with seven-transmembrane domain and is expressed in human melanocytes.
Immunogen
The antiserum was produced against synthesized peptide derived from human FZD3.
Immunogen Range: 141-190
Application
Anti-FZD3 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Mutation in FZD3 (frizzled class receptor 3) gene might account for Hirschsprung disease, a birth defect lacking the intrinsic ganglion cells of the lower intestine. FZD3 regulates the growth of longitudinal axon tracts in the central nervous system. FZD3 mediates the dynamics of axon within the enteric, sympathetic and peripheral nervous systems. FZD3 regulates planar cell polarity. Abnomal FZD3 gene methylation causes chromatin structure modifications, associated with congenital hydrocephalus.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 76 kDa |
| species reactivity | mouse, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:1000,immunofluorescence: 1:100-1:500,western blot: 1:500-1:1000 |
| NCBI accession no. | Q9NPG1 |
| UniProt accession no. | Q9NPG1 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... FZD3(7976) |
