产品介绍
Product Description
Application
氨基蝶呤已被用于生产抗神经颗粒蛋白抗体。
Biochem/physiol Actions
研究发现氨基蝶呤在小鼠模型中抑制生长、胚胎形成并具有毒性作用。它起堕胎药的作用。现已确知氨基蝶呤可减轻儿童急性白血病的影响。
与二氢叶酸还原酶结合并抑制其活性的叶酸拮抗剂。
叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。
Other Notes
比甲氨喋呤更有效，但毒性也更强。
技术参数
Specifications
| biological source | synthetic (organic) |
| Quality Level | 200 |
| product line | BioReagent |
| assay | ≥97% |
| form | powder |
| technique(s) | cell culture | mammalian: suitable |
| color | yellow |
| solubility | 2 M NaOH: 50 mg/mL,DMSO: soluble |
| ε (extinction coefficient) | 24,500 at 282 nm in 0.1 M NaOH at 1 M,25,700 at 261 nm in 0.1 M NaOH at 1 M,8,100 at 373 nm in 0.1 M NaOH at 1 M |
| web metadata keyword.default | Sigma-Aldrich A3411, Aminopterin powder, BioReagent, suitable for cell culture, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid, folic acid analogue, DHFR inhibitor, antifolate, hybridoma selection agent |
| shipped in | dry ice |
| storage temp. | −20°C |
| SMILES string | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |
| InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 |
| InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N |
| Gene Information | human ... FPGS(2356) mouse ... Fpgs(14287) |
