Application
Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.
Biochem/physiol Actions
C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.
Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
| biological source | human plasma |
| Quality Level | 200 |
| assay | ≥90% (SDS-PAGE) |
| form | liquid |
| concentration | 1 mg/mL in PBS, pH 7.2 |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P08603 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... CFH(3075) |
