General description
Gremlin-1 (GREM1) is part of the secreted, cysteine knot DAN family of bone morphogenetic protein antagonists. It has a molecular weight of 24–26kDa.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Gremlin-1 (GREM1) has a role in embryogenesis. It also has a role in cell functions during development. GREM1 acts as an antagonist of bone morphogenetic proteins (BMP). The protein influences chondrogenesis, outgrowth and apoptosis in limb bud development and has a role in kidney formation. It inhibits the activity of BMP2 and BMP4. GREM1 is involved in angiogenesis, bone formation, bone mass and pulmonary hypertension. Knockout of this gene in mice leads to developmental abnormalities.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
| species reactivity | mouse |
| packaging | kit of 96 wells (12 strips x 8 wells) |
| technique(s) | ELISA: suitable |
| input | sample type serum sample(s) sample type cell culture supernatant(s) sample type plasma |
| assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 0.8 ng/ml |
| detection method | colorimetric |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | mouse ... Grem1(23892) |
