产品介绍
Product Description
Biochem/physiol Actions
Davunetide (NAPVSIPQ; NAP) is an eight amino acid peptide identified as the active component of activity-dependent neuroprotective protein (ADNP). It has been found to be neuro-protective at femtomolar concentrations in vitro against the neural toxicity of a wide range of compounds. Davunetide has been investigated for Parkinson′s disease and schizophrenia and in clinical trials for Alzheimner′s Disease, targeting microtubule-tau Interaction.
Neuroprotective peptide; the neuronal tubulin-preferring agent
技术参数
Specifications
| assay | ≥95% (HPLC) |
| form | powder |
| composition | Peptide content, ≥60% |
| color | white to beige |
| shipped in | wet ice |
| storage temp. | −20°C |
| SMILES string | N2([C@@H](CCC2)C(=O)N[C@@H](CCC(=O)N)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)N)C)C(C)C)CO)[C@H](CC)C |
| InChI | 1S/C36H60N10O12/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58)/t18-,19-,20-,21-,22-,23-,24-,27-,28-/m0/s1 |
| InChI key | DWLTUUXCVGVRAV-XWRHUKJGSA-N |
