产品介绍
Product Description
Application
LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.
Biochem/physiol Actions
LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.
LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | oil |
| storage condition | desiccated |
| color | colorless to yellow |
| storage temp. | 2-8°C |
| SMILES string | Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1 |
| InChI | 1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H |
| InChI key | LLIHJRRZJDEKLB-UHFFFAOYSA-N |
