产品介绍
Product Description
Biochem/physiol Actions
Orally bioavailable, non-toxic, covalent inactivator of cathepsin L and other cysteine proteases including Schistosoma mansoni SmCB1 and cruzain; reduces SARS-CoV-2 viral infectivity with no effect on PLpro and Mpro.
K11777 is an orally bioavailable, non-toxic, dipeptidyl vinyl-sulfone analog that acts as a potent, covalent inactivator of cathepsin L and other cysteine proteases. Reduces SARS-CoV-2 viral infectivity (EC50 = 74, <80 and 4 nM for Vero E6, A549/ACE2, and HeLa/ACE2 cells, respectively) with no effect on papain-like (PLpro) and 3CL cysteine proteases (Mpro), encoded by SARS-CoV-2 at ≤ 100 µM. K11777 inhibits Schistosoma mansoni cathepsin B1 (SmCB1) and cruzain. Displays broad-spectrum anti-parasitic activities.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | CN1CCN(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC3=CC=CC=C3)/C=C/S(C4=CC=CC=C4)(=O)=O)=O)=O)CC1 |
