General description
Periostin (POSTN) is also known as osteoblast-specific factor-2. It is a 90 kDa protein expressed in the extracellular matrix and bones. POSTN is an adhesive glycoprotein. The gene encoding this protein is localized on human chromosome 13q13.3.
Immunogen
human Periostin recombinant protein. The human protein shares 87% homology with the mouse protein.
Application
Monoclonal Anti-Periostin antibody produced in mouse has been used to develop a periostin imaging PET probe.
Biochem/physiol Actions
Periostin (POSTN) has a role in the differentiation and cell adhesion of osteogenic cells. It functions as a biomarker of T-helper cells type 2-mediated inflammatory diseases. The protein has been associated with various cancers. POSTN is involved in epithelial-mesenchymal transition and extracellular matrix degradation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| conjugate | unconjugated |
| antibody form | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone | 47, monoclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~88 kDa |
| species reactivity | human |
| concentration | ~1.0 mg/mL |
| technique(s) | western blot: 2-4 μg/mL using whole extracts of HEK-293T cells over expressing human Periostin |
| isotype | IgG1 |
| UniProt accession no. | Q15063 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... POSTN(10631) |
