General description
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen
A phospho specific peptide corresponding to residues surrounding S474 of human PAK4
Physical form
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | monoclonal |
| form | liquid |
| species reactivity | mouse, human |
| concentration | 1.65 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no. | (O96013(PAK4-Antigen),Q9P286(PAK5),Q9NQU5(PAK6)) |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer474/pSer560/pSer602) |
