产品介绍
Product Description
Biochem/physiol Actions
PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to brown |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | room temp |
| SMILES string | CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.[H]Cl |
| InChI | 1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3 |
| InChI key | AZEXWHKOMMASPA-UHFFFAOYSA-N |
