PSEM89S Hydrochloride salt，25MG，SML3070-25MG，Sigma

Biochem/physiol Actions

PSEM agonist for chimeric ligand-gated ion channel pores with nAChR α7 LBD L141F or L141F/Y115F mutant (PSAM) in vitro and in vivo.
PSEM89S is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML^141F-GlyR & PSAML^141F/Y115F-GlyR). 5-HT3 (PSAML^141F-5-HT3 & PSAML^141F/Y115F-5-HT3) and high-conductance 5-HT3 (PSAML^141F-5-HT3 HC & PSAML^141F/Y115F-5-HT3 HC).