General description
WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
Application
WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response. WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.
Biochem/physiol Actions
Potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
Features and Benefits
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: ≥20 mg/mL |
| originator | Wyeth |
| storage temp. | 2-8°C |
| SMILES string | Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2 |
| InChI | 1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H |
| InChI key | BAAILVWEAXFTSF-UHFFFAOYSA-N |
