General description
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
Immunogen
A synthetic phosphorylated peptide around Y505 of human Lck (NP_001036236.1).
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| species reactivity | mouse, rat, human |
| concentration | 3.79 mg/mL |
| technique(s) | immunohistochemistry: 1:50-1:200,western blot: 1:500-1:1000 |
| UniProt accession no. | P06239 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr505) |
| Gene Information | human ... LCK(3932) |
