General description
Cut homeobox 1 (CUX1) is a transcription factor that contains three major domains, which include four DNA binding domains, three CUT domains or repeats (C1, C2, and C3), and a Cut homeodomain. It is expressed in multiple isoforms.
Immunogen
CUX1 (AAH25422.1, 1 a.a. ~ 676 a.a) full-length human protein.
Sequence
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSESAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNVKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ
Biochem/physiol Actions
Cut homeobox 1 (CUX1) binds to DNA and is involved in DNA repair. It stimulates the 8-oxoguanine-DNA glycosylase 1 (OGG1), a prime enzyme that acts on oxidative purine lesions and may have an indirect influence on radioresistance. Haploinsufficiency of CUX1 may have an impact on developmental delay (DD) and mild intellectual disability(ID). The multiple isoforms of CUX1 may have implications on various physiological pathologies like polycystic kidney disease and tumor development. In cortical neurons, CUX1 may play a key role in regulating spine development, dendritic branching, and synapse formation. CUX1 is a tumor suppressor gene and its deletion is implicated in high-risk acute myeloid leukemia.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~77.2 kDa |
| species reactivity | human |
| technique(s) | indirect immunofluorescence: suitable,western blot: 1 μg/mL |
| NCBI accession no. | BC025422.2 |
| UniProt accession no. | P39880 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CUX1(1523) |
