Anti-VMP1 antibody produced in rabbit，100UL，HPA030773-100UL，Sigma

General description

VMP1 (vacuole membrane protein 1) gene is mapped to human chromosome 17q23.1. VMP1 is a conserved multi-spanning transmembrane protein. The protein contains many endoplasmic reticulum micro-domains and six hydrophobic regions. It localizes to the intracellular membranes of the endoplasmic reticulum and the Golgi apparatus.

Immunogen

transmembrane protein 49 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

VMP1 (vacuole membrane protein 1) is associated with the process of tumor metastasis and is strongly involved in balancing apoptosis and autophagy. Depletion of VMP1 (vacuole membrane protein 1) in HeLa (immortal cell line) cells might inhibit autophagy. VMP1 might serve as a therapeutic target in human ovarian cancer, as its regulation is associated with the apoptosis and metastasis of ovarian cancer. Downregulation of VMP1 might reduce cancer cell growth and metastasis. VMP1 is considered as stress-inducible gene in organs affected by acute inflammatory responses. VMP1 is also known to support tight junction formation and cell-cell contacts by its interaction with Zonula Occludens-1 protein. The protein thus plays a role in maintaining the integrity and function of many membranous organelles in an evolutionarily conserved manner.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Other Notes

Corresponding Antigen APREST86416

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.