产品介绍
Product Description
General description
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Immunogen
A phospho specific peptide corresponding to residues surrounding S2 of human POLR2A
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Preparation Note
Store at -20℃. Avoid freeze / thaw cycles.
技术参数
Specifications
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 217, 63 |
| species reactivity | rat, human |
| concentration | 1.20 mg/ml |
| technique(s) | immunofluorescence: 1:50-1:100,immunoprecipitation (IP): 1:50-1:100,western blot: 1:1000-1:2000 |
| UniProt accession no. | P24928 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer2) |
| Gene Information | human ... POLR2A(5430) |
