产品介绍
Product Description
Biochem/physiol Actions
Potent and selective glycogen synthase kinase-3 (GSK3⍺/β) inhibitor.
SGC-GSK3-1 is a potent and selective glycogen synthase kinase-3 inhibitor (GSK3⍺/β IC50 = 1/2 nM by cell-free enzymatic assay, 4.6/12 nM by cellular NanoBRET) that protects iPSC-derived motor neurons from ER stress-induced death.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(NCC1CCOCC1)C2=NNC=C2NC(C3=C(C=CC=C3F)F)=O |
