产品介绍
Product Description
Application
7-Ethyl-10-hydroxycamptothecin has been used:
- to inhibit enterovirus 71 (EV71) (H) infection
- to screen the chemosensitivity of pancreatic adenocarcinoma cells
- as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters
Biochem/physiol Actions
Active metabolite of irinotecan. Inhibitor of topoisomerase I.
Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.
技术参数
Specifications
| biological source | Artemisia annua |
| Quality Segment | 200 |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | DMSO: 1 mg/mL |
| storage temp. | −20°C |
| SMILES string | OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O |
| InChI | 1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1 |
| InChI key | FJHBVJOVLFPMQE-QFIPXVFZSA-N |
