Immunogen
The epitope recognized by PLA0235 maps to a region between residue 329 and 379 of human extracellular signal-related kinase 1 (mitogen-activated protein kinase 3) using the numbering given in entry NP_002737.2 (GeneID 5595).
Physical form
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
Other Notes
Extracellular signal-regulated kinase 1 (ERK1/p44) is also known as mitogen-activated protein kinase 3 (MAPK3). ERK1 is part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:100-1:500,immunoprecipitation (IP): 2- 5 μg/mg,western blot: 1:2,000- 1:10,000 |
| accession no. | NP_002737.2 |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | rabbit ... ERK1(5595) |
