General description
EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) is an intracellular protein that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. The protein contains two RNA binding domains and a kinase domain. The PKR gene is localized on human chromosome 2p22-p21.
Immunogen
PKR antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PKR.
Application
Anti-PKR antibody produced in rabbit has been used in Western Blotting.
Biochem/physiol Actions
EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral responses promoted by interferons. It is involved in stress response and inflammation pathways. EIF2AK2 controls the development and multiplication of cells, nutrient signaling and metabolism. The protein also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500326.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human, mouse, rat |
| technique(s) | immunofluorescence: suitable,immunohistochemistry: suitable,indirect ELISA: suitable,western blot: suitable |
| NCBI accession no. | AAP57628 |
| UniProt accession no. | P19525 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... EIF2AK2(5610) |
