Immunogen
Synthetic peptide directed towards the N terminal region of human NR0B1
Application
Anti-NR0B1 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.
Biochem/physiol Actions
Nuclear receptor subfamily 0, group B, member 1 (NR0B1; DAX-1) is a DNA-binding protein that negatively regulates retinoic acid receptor-mediated transcription. It is an antagonist to the protein Sry and functions as an anti-testis protein. Mutations in gene encoding NR0B1 result in primary adrenal insufficiency or congenital adrenal hypoplasia in early childhood and hypogonadotropic hypogonadism.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: TSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCC
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 52 kDa |
| species reactivity | human |
| concentration | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| web metadata keyword.default | 2.5µg/ml Anti-NR0B1 antibody,4-8µg/ml Anti-NR0B1 antibody for paraffin-embedded tissue,Anti-DAX-1 antibody immunohistochemistry,Anti-NR0B1 antibody for research,Anti-NR0B1 antibody immunohistochemistry,Anti-NR0B1 antibody in PBS buffer,Anti-NR0B1 antibody rabbit,Anti-NR0B1 antibody,Anti-Nuclear receptor subfamily 0, group B, member 1 antibody,Sigma-Aldrich Anti-NR0B1 antibody,anti-DAX1 antibody for western blot,immunohistochemistry grade Anti-NR0B1 antibody,purified Anti-NR0B1 antibody for western blotting,rabbit polyclonal Anti-NR0B1 antibody,synthetic peptide Anti-NR0B1 antibody |
| NCBI accession no. | NP_000466 |
| UniProt accession no. | P51843 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... NR0B1(190) |
