产品介绍
Product Description
Biochem/physiol Actions
AZD3463 is an orally available, potent receptor tyrosine kinase (RTK) inhibtor against anaplastic lymphoma kinase ALK (Ki = 0.75 nM; IC50 = 15-21 nM with 5FAM-Srctide as substrate & 30 μM ATP), insulin-like growth factor (IGF)-1 receptor (IGF1R), ROS1 (c-Ros), and Trk-A (NTRK1). AZD3463 effectively inhibits multiple crizotinib-resistant cancer growth and displays in vivo efficacy against FLT3-ITD-dependent MOLM-13 acute myeloid leukemia (AML) as well as NGP (wt ALK) & SH-SY5Y (ALK-F1174L) neuroblastoma in mice (15 mg/kg ip.).
Orally available, potent RTK inhibtor against anaplastic lymphoma kinase (ALK), IGF1R, ROS1 and Trk-A (NTRK1) with in vitro and in vivo anticancer efficacy.
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| web metadata keyword.default | AZD3463 1356962-20-3 CAS number,AZD3463 ALK inhibitor research product,AZD3463 IGF1R inhibitor for cancer studies,AZD3463 N-(4-(4-Amino-1-piperidinyl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine,AZD3463 cancer therapy reagent,AZD3463 chemical structure N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine,AZD3463 for FLT3-ITD-dependent acute myeloid leukemia,AZD3463 for cancer research,AZD3463 for crizotinib-resistant cancer,AZD3463 oral availability cancer treatment,AZD3463 potency IC50 15-21 nM,AZD3463 procurement for laboratory use,AZD3463 receptor tyrosine kinase inhibitor,AZD3463 research grade inhibitor,Sigma-Aldrich AZD3463 for neuroblastoma |
| storage temp. | −20°C |
| SMILES string | ClC1=CN=C(N=C1C2=CNC3=C2C=CC=C3)NC4=CC=C(C=C4OC)N5CCC(CC5)N |
| InChI | 1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30) |
| InChI key | GCYIGMXOIWJGBU-UHFFFAOYSA-N |
