General description
Anti-MAP4 antibody detects endogenous levels of total MAP4 protein.MAP4 (microtubule-associated protein 4) is mapped to human chromosome 3p21.31. The encoded protein is ubiquitously expressed in all cells except for the neurons. MAP4 structure contains a projection domain and a microtubule-binding (MTB) domain at the N- and C-terminal respectively.
Immunogen
The antiserum was produced against synthesized peptide derived from human MAP4.
Immunogen Range: 662-711
Biochem/physiol Actions
Microtubule-associated protein 4 (MAP4) affects microtubule assembly, stabilization and dynamics through septin interaction. MAP4 promotes apoptosis by p53 regulation. MAP4 mediates the involvement of microtubules in cell division and migration, vesicular transport or generation of primary cilia. It specifically influences mitotic spindle and centrosome position. It is known to stimulate type I IFN (interferon) signaling, which is necessary for innate immune response. MAP4 is associated with the process of invasion and metastasis of esophageal squamous cancer. It might serve as a biomarker for the same.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 121 kDa |
| species reactivity | human, mouse, rat |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:1000,immunofluorescence: 1:100-1:500,immunohistochemistry: 1:50-1:100 |
| NCBI accession no. | P27816 |
| UniProt accession no. | P27816 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... MAP4(4134) |
