产品介绍
Product Description
General description
IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 100 μL deionized water.
Other Notes
IL-36alpha (mouse) (aa 8-160) is untagged.
技术参数
Specifications
| biological source | mouse |
| recombinant | expressed in E. coli |
| conjugate | untagged |
| assay | >95% (SDS-PAGE) |
| form | lyophilized |
| mol wt | ~17 kDa |
| packaging | pkg of 10 μg |
| impurities | <0.01 EU/μg endotoxin, tested |
| UniProt accession no. | Q9JLA2 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | mouse ... Il36a(54448) |
