General description
AIFM1 (apoptosis inducing factor mitochondria associated 1) codes for apoptosis-inducing factor 1(AIF). It is located on human chromosome Xq26.1. AIF is a caspase-independent cell death effector.
Immunogen
Purified recombinant fragment of human AIF expressed in E.coli.
Mouse monoclonal antibody raised against AIF
Biochem/physiol Actions
AIFM1 (apoptosis inducing factor mitochondria associated 1) possesses redox activity, which helps in oxidative phosphorylation. In the mitochondria, AIFM1 helps in assembling or maintaining the mitochondrial respiratory complexes I and III. It plays a vital role in apoptosis. This gene is associated with COXPD6 (combined oxidative phosphorylation deficiency, encephalomyopathy, Cowchock syndrome and X-linked deafness with neuropathy.
Physical form
Ascitic fluid containing 0.03% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| clone | 4E7, monoclonal |
| mol wt | 67 kDa |
| species reactivity | mouse, monkey, human, rat |
| technique(s) | direct ELISA: 1:10,000,flow cytometry: 1:200-1:400,immunohistochemistry: 1:200-1:1,000,indirect immunofluorescence: 1:200-1:1,000,western blot: 1:500-1:2,000 |
| isotype | IgG2b |
| NCBI accession no. | NM_001130846 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... AIF(9131) |
