General description
GJA3, an integral membrane protein, belong to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and nonjunctional (′hemi-′) channels. Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3), a form of autosomal dominant congenital cataract.
Immunogen
GJA3 (NP_068773, 112-148)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GJA3.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100,indirect ELISA: 1:1000,western blot: 1:100-1:500 |
| NCBI accession no. | NP_068773 |
| UniProt accession no. | Q9Y6H8 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... GJA3(2700) |
