产品介绍
Product Description
Biochem/physiol Actions
(S)-GSK2920487A is a promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani. (S)-GSK2920487A induces the accumulation of the 2,3-oxidosqualene, a substrate of OSC, in promastigotes and cell-free membrane preparations. It is active against axenic and intramacrophage amastigotes. Also, GSK2920487A is active against intracellular T. cruzi.
promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to gray |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C(N1C[C@H](CCC1)N2C=CN=C2C)C3=CC4=C(S3)C=CC=C4F |
| InChI | 1S/C18H18FN3OS/c1-12-20-7-9-22(12)13-4-3-8-21(11-13)18(23)17-10-14-15(19)5-2-6-16(14)24-17/h2,5-7,9-10,13H,3-4,8,11H2,1H3/t13-/m0/s1 |
| InChI key | SBZYUUGJHIROPT-ZDUSSCGKSA-N |
