General description
APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) is a neuronal adaptor protein belonging to the X11 family. It consists of a centrally located phosphotyrosine binding domain which inhibits the production of Aβ peptide, two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains.
Immunogen
Peptide with sequence C-EASHPSQDGKRQYK from the internal region of the protein sequence according to NP_001154.2.
Application
Anti-APBA1/MINT1 antibody produced in goat is suitable for indirect ELISA and western blot analysis.
Biochem/physiol Actions
APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) stabilizes amyloid precursor protein (APP) by directly interacting with it. It also restricts production as well as accumulation of proteolytic APP fragment in the brain of Alzheimer′s disease patients. It also suppresses glycogen synthase kinase-3β promoter activity by coupling with a silencer binding protein.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
| biological source | goat |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | mouse, human, rat |
| technique(s) | indirect ELISA: suitable,western blot: suitable |
| UniProt accession no. | Q02410 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... APBA1(320) |
