General description
MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. This gene is expressed in neurons but is most prominent in axons.
Immunogen
The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Thr181.
Immunogen Range: 471-520
Biochem/physiol Actions
MAPT (microtubule associated protein tau) participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure. Removal of MAPT results in developmental delay and learning disability.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 78 kDa |
| species reactivity | rat, human, mouse |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:20000,western blot: 1:500-1:1000 |
| NCBI accession no. | P10636 |
| UniProt accession no. | P10636 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr181) |
| Gene Information | human ... MAPT(4137) |
