Anti-TULP3 antibody produced in rabbit，100UL，HPA015285-100UL，Sigma

General description

TULP3 (tubby like protein 3) is a member of the tubby-like protein (TULP) family. This family contains three members namely, TULP1, 2 and 3. TULP proteins, along with Tubby (Tub) form a small gene family. TULP3 has a ubiquitous expression pattern during embryonic development. It contains a characteristic conserved tubby domain present at its C-terminal. This protein is a resident of cilia. Its N-terminal contains a conserved α-helical region, which interacts with IFT (Intraflagellar transport)-A complex. This gene is localized to human chromosome 12p13, and codes for a protein composed of 442 amino acids. In humans, it is also expressed in thyroid, ovaries, testis and spinal cord.

Immunogen

Tubby-related protein 3 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

TULP3 (tubby like protein 3) plays an essential role in the development and function of neuronal cells. It interacts with the core proteins, IFT122, IFT140, and WDR19 (WD repeat domain 19), of IFT (Intraflagellar transport)-A complex. This results in the trafficking of GPCRs (G-protein coupled receptors) to the cilia. Studies in mice embryos show that this protein is a negative regulator of hedgehog (Hh) signaling, and TULP3, in association with IFT-A, regulate patterning of neural tube. It is highly up-regulated in pancreatic adenocarcinoma, and might be involved in the progression of the same. Thus, this protein might serve as a marker to determine the prognosis of pancreatic adenocarcinoma.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST73678

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.