产品介绍
Product Description
Biochem/physiol Actions
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | desiccated |
| solubility | DMSO: ≥9 mg/mL |
| web metadata keyword.default | γ-secretase active site inhibitor III-31-C,CAS 398515-96-3 III-31-C,DAPT and III-31-C γ-secretase inhibitors,III-31-C γ-secretase inhibitor,III-31-C for protease complex characterization,III-31-C for testing γ-secretase inhibitors,III-31-C hydroxyethyl urea,III-31-C inhibitor for biochemical assays,N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester,Sigma-Aldrich III-31-C research chemical,Sigma-Aldrich III-31-C,affinity isolation γ-secretase inhibitor III-31-C,lab-grade III-31-C γ-secretase inhibitor |
| storage temp. | −20°C |
| SMILES string | COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc2ccccc2)C(C)C |
| InChI | 1S/C35H52N4O7/c1-23(2)19-28(31(41)38-30(24(3)4)32(42)45-8)36-33(43)39(21-26-17-13-10-14-18-26)22-29(40)27(20-25-15-11-9-12-16-25)37-34(44)46-35(5,6)7/h9-18,23-24,27-30,40H,19-22H2,1-8H3,(H,36,43)(H,37,44)(H,38,41)/t27-,28-,29+,30?/m0/s1 |
| InChI key | DINAVFJXFRFCRE-BLFWRVEASA-N |
