General description
Cyclin D3 is a regulator of cell proliferation and cell-cycle progression during G1/S transition. It is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family. It is over-expressed or amplified in various human tumors such as acute myeloid leukemia and Burkitt′s lymphoma.
Immunogen
Synthetic peptide derived human cyclin D3 protein.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| recombinant | expressed in proprietary host |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | SP207, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | rat, mouse, bovine |
| technique(s) | flow cytometry: 1:100,immunoblotting: 1:100,immunohistochemistry: 1:100 |
| isotype | IgG |
| UniProt accession no. | P30281 |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CCND3(896) |
