Biochem/physiol Actions
Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
Paroxetine maleate is a selective serotonin reuptake inhibitor; antidepressant.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold with the permission of GlaxoSmithKline
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to off-white |
| solubility | DMSO: ~12 mg/mL,H2O: insoluble |
| originator | GlaxoSmithKline |
| storage temp. | 2-8°C |
| SMILES string | OC(=O)\C=C/C(O)=O.Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3 |
| InChI | 1S/C19H20FNO3.C4H4O4/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;5-3(6)1-2-4(7)8/h1-6,9,14,17,21H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,17-;/m0./s1 |
| InChI key | AEIUZSKXSWGSRU-QXGDPHCHSA-N |
| Gene Information | human ... SLC6A4(6532) |
