产品介绍
Product Description
Biochem/physiol Actions
Mutant p53 stabilizer
PhiKan083 is a small molecule that binds within a cavity on the surface of Y220C-mutated p53. This mutation, which is not involved in DNA interaction, causes a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl |
| InChI key | IXWVUPURFWFRNE-UHFFFAOYSA-N |
