General description
KMT6/Enhancer of zeste homologue 2 (EZH2) is a histone lysine methyl transferase associated with transcriptional repression. It is a component of the polycomb repressive complexes PRC2 and PRC3. The PRC2 complex catalyses histone H3 K27 trimethylation. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. EZH2 is highly expressed in follicular T-cells and in a variety of tumors such as lymphoma, breast and prostate.
Immunogen
Synthetic peptide corresponding to C-terminus of human EZH2 protein.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| recombinant | expressed in proprietary host |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | SP129, monoclonal |
| species reactivity | human (tested) |
| species reactivity (predicted by homology) | monkey, frog, mouse, rat |
| technique(s) | flow cytometry: 1:100,immunoblotting: 1:25,immunohistochemistry: 1:100 |
| isotype | IgG |
| UniProt accession no. | Q15910 |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... EZH2(2146) |
