PHA-680632，5MG，SML3721-5MG，Sigma

Biochem/physiol Actions

Potent and selective Aurora kinase inhibitor with anti-cancer efficacy in cultures and in animals in vivo.

PHA-680632 is a potent and selective Aurora kinase inhibitor (Aurora A/B/C IC50 = 27/135/120 nM; FGFR1 IC50 = 390 nM, 30- to 200-fold selectivity for Aurora A over 6 other kinases and IC50 >10 μM against 22 kinases) with antiproliferation activity in cancer cultures (IC50 ranges from 60 nM to 7.15 μM) and anti-tumor efficacy in mice and rats in vivo (15-60 mg/kg i.v. b.i.d. or 15-45 mg/kg i.p. t.i.d.)