General description
Glypican-3 (GPC3) is a cell surface proteoglycan that bears heparan sulfate. It may be involved in the suppression/modulation of growth in the predominately mesodermal tissues and organs. Alteration of GPC3 expression is associated with several malignancies such as hepatocellular carcinoma (HCC). This antibody can be used to detect GPC3 in both normal and neoplastic tissue types. This antibody should not be used to differentiate hepatocellular carcinoma (HCC) from either normal liver or other types of liver disease.
Immunogen
Synthetic peptide derived from C-terminus of human glypican-3 protein.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| recombinant | expressed in proprietary host |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | SP86, monoclonal |
| species reactivity | human (tested) |
| technique(s) | flow cytometry: 1:100,immunoblotting: 1:25,immunohistochemistry: 1:100 |
| isotype | IgG |
| UniProt accession no. | P51654 |
| shipped in | wet ice |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... GPC3(2719) |
