General description
Glial cell derived neurotrophic factor (GDNF) is encoded by the gene mapped to human chromosome 5p14.1−q13.3. It belongs to the transforming growth factor β (TGF-β) superfamily. GDNF is abundantly found in gliomas.
Immunogen
Recombinant Human GDNF
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Glial cell derived neurotrophic factor (GDNF) is a neurotrophic factor involved in dopaminergic and neurodevelopment. It plays a vital role in self-renewal of stem cells. In addition, GDNF also facilitates differentiation of chained undifferentiated spermatogonia. GDNF with its receptors, activates various signaling pathways essential for maintaining cellular homeostasis. Mutated gene is associated with the development of schizophrenia. GDNF is a potential target for treating Parkinson′s disease.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
| species reactivity | human |
| packaging | kit of 96 wells (12 strips x 8 wells) |
| technique(s) | ELISA: suitable,capture ELISA: suitable |
| input | sample type serum sample type urine sample type cell culture supernatant(s) sample type plasma |
| assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 4 pg/mL standard curve range: 2.74-2000 pg/mL |
| detection method | colorimetric |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... GDNF(2668) |
