产品介绍
Product Description
Application
根赤壳菌素（来源于Diheterospora chlamydosporia）作为热休克蛋白90(Hsp90)抑制剂已用于：
- 研究其对秀丽隐杆线虫寿命延长和健康的影响
- 研究其对酵母蛋白聚集的影响
- 研究其对氧杂蒽酮敏化癌细胞的影响
Biochem/physiol Actions
根赤壳菌素是一种抗真菌大环内酯抗生素，存在于Diheterospora chlamydosporia、Chaetomium chiversii和Monosporium bonorden真菌中。它可用作酪氨酸激酶和热休克蛋白90(Hsp90)的抑制剂。根赤壳菌素参与抑制Ras、Mos和Src等各种原癌基因转化。它还可抑制丝裂原诱导型一氧化氮合酶(COX-2)和磷脂酰肌醇依赖性蛋白激酶1(PDK1)的活性。根赤壳菌素参与将细胞周期阻滞在G1-S期。它在体内具有抗癌和抗血管生成活性。
Disclaimer
光敏性
技术参数
Specifications
| form | solid |
| Quality Level | 200 |
| greener alternative product score | old score: 15 new score: 9 Find out more about DOZN™ Scoring |
| greener alternative product characteristics | Waste Prevention Atom Economy Use of Renewable Feedstocks Learn more about the Principles of Green Chemistry. |
| sustainability | Greener Alternative Product |
| color | white to yellow-white |
| solubility | ethanol: 10 mg/mL |
| antibiotic activity spectrum | fungi |
| greener alternative category | , Re-engineered |
| mode of action | enzyme | inhibits |
| storage temp. | −20°C |
| SMILES string | C[C@@H]1C[C@H]2O[C@@H]2C=C\C=C\C(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1 |
| InChI | 1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1 |
| InChI key | WYZWZEOGROVVHK-GTMNPGAYSA-N |
| Gene Information | human ... HSP90AA1(3320), SRC(6714) rat ... Src(83805) |
