产品介绍
Product Description
General description
Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.
Application
Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
技术参数
Specifications
| biological source | synthetic (organic) |
| Quality Level | 200 |
| sterility | non-sterile |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | H2O: insoluble,acetone: soluble (1 in 30),alcohol: soluble (1 in 50),chloroform: freely soluble,dioxane: slightly soluble,vegetable oils: slightly soluble |
| shipped in | ambient |
| storage temp. | room temp |
| SMILES string | [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O |
| InChI | 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1 |
| InChI key | VPGRYOFKCNULNK-ACXQXYJUSA-N |
| Gene Information | human ... NR3C2(4306) |
